Clownfish Metamorphosis Regulation by Thyroid Hormones
Most marine organisms exhibit a biphasic life cycle, during which pelagic larvae undergo a dramatic transformation into juveniles. In vertebrates, thyroid hormones (THs) are known to play a crucial role in initiating this transition. However, the precise mechanisms by which morphological and physiological changes are integrated with ecological shifts remain largely unexplored.
To address this gap, researchers conducted an integrated analysis of the metamorphosis of a marine teleost, the false clownfish (Amphiprion ocellaris). The study reveals how THs orchestrate a change in color vision and a significant metabolic shift in energy production, underscoring their pivotal role in this transformation.
By manipulating the activity of liver X receptor (LXR), a key regulator of metabolism, the researchers uncovered a strong link between metabolic changes and the progression of metamorphosis. Remarkably, these regulatory mechanisms were observed in natural settings, demonstrating how hormones coordinate energy demands with available resources throughout the life cycle.
This comprehensive study, published in Cell Reports, not only sheds light on the intricate mechanisms governing clownfish metamorphosis but also provides valuable insights into the ecological transitions of marine organisms. The findings highlight the importance of understanding the interplay between hormonal signals and environmental cues in shaping the life history of marine species.
We would like to congratulate the teams of Vincent Laudet from the Okinawa Institute of Science and Technology and Laurence Bessot from the Observatoire océanologique de Banyuls-sur-Mer, along with their collaborators, for this insightful research.
Contribution of AltraBio
In this study, AltraBio played a pivotal role by conducting the analysis of RNA-Seq data. We are grateful for this fruitful collaboration, which has significantly contributed to the success of this research.
Publication Details
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