Publications

@article{pmid39204272,

title = {BacSPaD: A Robust Bacterial Strains' Pathogenicity Resource Based on Integrated and Curated Genomic Metadata},

author = {Sara Ribeiro and Guillaume Chaumet and Karine Alves and Julien Nourikyan and Lei Shi and Jean-Pierre Lavergne and Ivan Mijakovic and Simon de Bernard and Laurent Buffat},

doi = {10.3390/pathogens13080672},

issn = {2076-0817},

year  = {2024},

date = {2024-08-01},

urldate = {2024-08-01},

journal = {Pathogens},

volume = {13},

number = {8},

abstract = {The vast array of omics data in microbiology presents significant opportunities for studying bacterial pathogenesis and creating computational tools for predicting pathogenic potential. However, the field lacks a comprehensive, curated resource that catalogs bacterial strains and their ability to cause human infections. Current methods for identifying pathogenicity determinants often introduce biases and miss critical aspects of bacterial pathogenesis. In response to this gap, we introduce BacSPaD (Bacterial Strains' Pathogenicity Database), a thoroughly curated database focusing on pathogenicity annotations for a wide range of high-quality, complete bacterial genomes. Our rule-based annotation workflow combines metadata from trusted sources with automated keyword matching, extensive manual curation, and detailed literature review. Our analysis classified 5502 genomes as pathogenic to humans (HP) and 490 as non-pathogenic to humans (NHP), encompassing 532 species, 193 genera, and 96 families. Statistical analysis demonstrated a significant but moderate correlation between virulence factors and HP classification, highlighting the complexity of bacterial pathogenicity and the need for ongoing research. This resource is poised to enhance our understanding of bacterial pathogenicity mechanisms and aid in the development of predictive models. To improve accessibility and provide key visualization statistics, we developed a user-friendly web interface.},

keywords = {medical data, omics},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {P-228 Les modèles mathématiques peuvent prédire l'activité des plaquettes humaines et les expressions protéiques en réponse à diverses stimulations},

author = {Fabrice Cognasse and Kim Anh Nguyen and Marco Heestermans and Charles-Antoine Arthaud and Marie-Ange Eyraud and Amélie Prier and Simon De Bernard and Julien Nourikyan and Anne-Claire Duchez and Stéphane Avril and Olivier Garraud and Hind Hamzeh-Cognasse},

doi = {10.1016/j.tracli.2023.09.272},

year  = {2023},

date = {2023-11-10},

urldate = {2023-11-10},

journal = {Transfusion Clinique et Biologique},

volume = {30},

issue = {S1},

pages = {S147},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations},

author = {Fabrice Cognasse and Kim Anh Nguyen and Marco Heestermans and Simon De Bernard and Julien Nourikyan and Anne-Claire Duchez and Stéphane Avril and Olivier Garraud and Hind Hamzeh-Cognasse},

doi = {10.1111/trf.199_17554},

year  = {2023},

date = {2023-10-12},

urldate = {2023-10-12},

journal = {Transfusion},

volume = {63},

issue = {S5},

pages = {156A-156A},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37275363,

title = {Ultrasound assessment of the respiratory system using diaphragm motion-volume indices},

author = {Alain Boussuges and Guillaume Chaumet and Martin Boussuges and Amelie Menard and Stephane Delliaux and Fabienne Brégeon},

doi = {10.3389/fmed.2023.1190891},

issn = {2296-858X},

year  = {2023},

date = {2023-05-19},

urldate = {2023-05-19},

journal = {Front Med (Lausanne)},

volume = {10},

pages = {1190891},

abstract = {BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.



METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.



RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.



CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36410115,

title = {Comprehensive morphometric assessment of deltoid muscle development in children: A cross-sectional study},

author = {Teresinha Evangelista and Malick Kandji and Emmanuelle Lacene and Anaïs Chanut and Mai Thao Bui and Rudy Marty and Laurent Buffat and Kenneth Knoblauch and Brian B Rudkin and Norma Beatriz Romero},

doi = {10.1016/j.ebiom.2022.104367},

issn = {2352-3964},

year  = {2022},

date = {2022-12-01},

urldate = {2022-12-01},

journal = {EBioMedicine},

volume = {86},

pages = {104367},

abstract = {BACKGROUND: Normative values for different morphometric parameters of muscle fibres during paediatric development, i.e. from 0 to 18 years, are currently unavailable. They would be of major importance to accurately evaluate pathological changes and could be used as reference biomarkers for evaluating treatment response in clinical trials, or physiological adjustments in sports or ageing.



METHODS: Data were derived from 482 images with a total of 33 094 fibres from 10 μm cross-sections of snap-frozen muscle from 83 deltoid muscle biopsies from patients, 0-18 years, without neuromuscular pathology stained with ATPase 9.4. Data was acquired and analysed with patented image analysis algorithms from "CARPACCIO.cloud". Several parameters were extracted or calculated, including cross-sectional area (CSA), fibre type, circularity, as well as the Minimum diameter of Feret (MinFeret).



FINDINGS: This study illustrates changes in quantitative parameters for muscle morphology over the course of paediatric development and the pivotal changes occurring around puberty. Only fibre size parameters (MinFeret, CSA) are dependent on gender, and only after puberty. All other parameters vary in a similar manner for females and males. The proportion of type 1 fibres is essentially constant from birth to age 10, decreasing to ≈40% by age 18. Circularity decreases with age, to plateau after age 10 for both fibre types.



INTERPRETATION: Normative values and reference charts for muscle fibre types in this age range have been generated to allow comparison of data from patients in pathology laboratories working on neuromuscular diseases.



FUNDING: BPI FRANCE, PULSALYS, Association de l'Institut de Myologie, French National Research Agency (ANR), LABEX CORTEX of Université de Lyon.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36091672,

title = {Diaphragm dysfunction after severe COVID-19: An ultrasound study},

author = {Alain Boussuges and Paul Habert and Guillaume Chaumet and Rawah Rouibah and Lea Delorme and Amelie Menard and Matthieu Million and Axel Bartoli and Eric Guedj and Marion Gouitaa and Laurent Zieleskiewicz and Julie Finance and Benjamin Coiffard and Stephane Delliaux and Fabienne Brégeon},

doi = {10.3389/fmed.2022.949281},

issn = {2296-858X},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Front Med (Lausanne)},

volume = {9},

pages = {949281},

abstract = {BACKGROUND: SARS-CoV-2 infection can impair diaphragm function at the acute phase but the frequency of diaphragm dysfunction after recovery from COVID-19 remains unknown.



MATERIALS AND METHODS: This study was carried out on patients reporting persistent respiratory symptoms 3-4 months after severe COVID-19 pneumonia. The included patients were selected from a medical consultation designed to screen for recovery after acute infection. Respiratory function was assessed by a pulmonary function test, and diaphragm function was studied by ultrasonography.



RESULTS: In total, 132 patients (85M, 47W) were recruited from the medical consultation. During the acute phase of the infection, the severity of the clinical status led to ICU admission for 58 patients (44%). Diaphragm dysfunction (DD) was detected by ultrasonography in 13 patients, two of whom suffered from hemidiaphragm paralysis. Patients with DD had more frequently muscle pain complaints and had a higher frequency of prior cardiothoracic or upper abdominal surgery than patients with normal diaphragm function. Pulmonary function testing revealed a significant decrease in lung volumes and DLCO and the dyspnea scores (mMRC and Borg10 scores) were significantly increased in patients with DD. Improvement in respiratory function was recorded in seven out of nine patients assessed 6 months after the first ultrasound examination.



CONCLUSION: Assessment of diaphragm function by ultrasonography after severe COVID-19 pneumonia revealed signs of dysfunction in 10% of our population. In some cases, ultrasound examination probably discovered an un-recognized pre-existing DD. COVID-19 nonetheless contributed to impairment of diaphragm function. Prolonged respiratory physiotherapy led to improvement in respiratory function in most patients.



CLINICAL TRIAL REGISTRATION: [www.cnil.fr], identifier [#PADS20-207].},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34916955b,

title = {Changes in Diaphragmatic Function Induced by an Increased Inspiratory Load Experienced by Military Divers: An Ultrasound Study},

author = {Sarah Rives and Bruno Schmid and Guillaume Chaumet and Fabienne Brégeon and Alain Boussuges},

doi = {10.3389/fphys.2021.756533},

issn = {1664-042X},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Front Physiol},

volume = {12},

pages = {756533},

abstract = { Inspiratory loading is experienced by military divers when they use rebreather device. Our objective was to assess the changes in diaphragm function induced by an increase in inspiratory load at values similar to those experienced by divers in real life. : We recorded the excursion and the thickness of the right hemidiaphragm in 22 healthy male volunteers under inspiratory load conditions, using ultrasound in B- and M-mode. The measurements were performed at tidal volume and during breathing at 50% of inspiratory capacity. The breathing rate was regulated and similar in the various sessions with and without load.  The rebreather device used by French military divers leads to an increase in inspiratory load of close to 30 cmHO. Consequently, the session under load was performed using a device set to this threshold. Significant increases in the excursion and the thickening fraction of the diaphragm were observed between the sessions at tidal volume and at high volume. With addition of the inspiratory load, the excursion of the right hemidiaphragm increased significantly from 2.3 to 3.4cm at tidal volume and from 3.9 to 4.7cm at high volume. The thickening fraction increased significantly from 30.4 to 76.6% at tidal volume and from 70 to 123% at high volume. The statistical analysis demonstrated that assessment of the changes of the thickening fraction during breathing at tidal volume was the most relevant marker to assess the impact of the inspiratory load on the diaphragm.  Diaphragm ultrasound can be used to assess the changes in the diaphragm contraction pattern secondary to an increase in the respiratory load that can be generated by use a diving apparatus. The recording of the changes of the motion, and more importantly of the thickness of the diaphragm, during the breathing cycle is able to provide relevant information regarding the inspiratory load.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33778044,

title = {Diaphragmatic motion recorded by M-mode ultrasonography: limits of normality},

author = {Alain Boussuges and Julie Finance and Guillaume Chaumet and Fabienne Brégeon},

doi = {10.1183/23120541.00714-2020},

issn = {2312-0541},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {ERJ Open Res},

volume = {7},

number = {1},

abstract = {Chest ultrasonography has proven to be useful in the diagnosis of diaphragm dysfunction. The aim of the present study was to determine the normal values of the motion of both hemidiaphragms recorded by M-mode ultrasonography. Healthy volunteers were studied while in a seated position. Diaphragmatic excursions and diaphragm profiles were measured during quiet breathing, voluntary sniffing and deep breathing. Diaphragmatic excursions were assessed by M-mode ultrasonography, using an approach perpendicular to the posterior part of the diaphragm. Anatomical M-mode was used for the recording of the complete excursion during deep breathing. The study included 270 men and 140 women. The diaphragmatic motions during quiet breathing and voluntary sniffing were successfully recorded in all of the participants. The use of anatomical M-mode was particularly suitable for measurement of the entire diaphragmatic excursion during deep breathing. The statistical analysis showed that the diaphragmatic excursions were larger in men compared to women, supporting the determination of normal values based on sex. The lower and upper limits of normal excursion were determined for men and women for both hemidiaphragms during the three manoeuvres that were investigated. The lower limits of normal diaphragmatic excursions during deep breathing should be used to detect diaphragmatic hypokinesia,  3.3 and 3.2 cm in women and 4.1 and 4.2 cm in men for the right and the left sides, respectively. The normal values of the diaphragmatic motion and the lower and upper limits of normal excursion can be used by clinicians to detect diaphragmatic dysfunction.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34778304b,

title = {Ultrasound Assessment of Diaphragm Thickness and Thickening: Reference Values and Limits of Normality When in a Seated Position},

author = {Alain Boussuges and Sarah Rives and Julie Finance and Guillaume Chaumet and Nicolas Vallée and Jean-Jacques Risso and Fabienne Brégeon},

doi = {10.3389/fmed.2021.742703},

issn = {2296-858X},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Front Med (Lausanne)},

volume = {8},

pages = {742703},

abstract = { Diagnosing diaphragm dysfunction in the absence of complete paralysis remains difficult. The aim of the present study was to assess the normal values of the thickness and the inspiratory thickening of both hemidiaphragms as measured by ultrasonography in healthy volunteers while in a seated position.  Healthy volunteers with a normal pulmonary function test were recruited. The diaphragmatic thickness was measured on both sides at the zone of apposition of the diaphragm to the rib cage during quiet breathing at end-expiration, end-inspiration, and after maximal inspiration. The thickening ratio, the thickening fraction, and the thickness at end-inspiration divided by the thickness at deep breathing were determined. The mean values and the lower and upper limits of normal were determined for men and women.  200 healthy volunteers (100 men and 100 women) were included in the study. The statistical analysis revealed that women had a thinner hemidiaphragm than men on both sides and at the various breathing times studied. The lower limit of normality of the diaphragm thickness measured at end-expiration was estimated to be 1.3 mm in men and 1.1 mm in women, on both sides. The thickening fraction did not differ significantly between men and women. In men, it ranged from 60 to 260% on the left side and from 57 to 200% on the right side. In women, it ranged from 58 to 264% on the left side and from 60 to 229% on the right side. The lower limits of normality of the thickening fraction were determined to be 40 and 39% in men and 39 and 48% in women for the right and left hemidiaphragms, respectively. The upper limit for normal of the mean of both sides of the ratio thickness at end-inspiration divided by the thickness at deep breathing was determined to be 0.78 in women and 0.79 in men.  The normal values of thickness and the indexes of diaphragmatic function should help clinicians with detecting diaphragm atrophy and dysfunction.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32052923,

title = {AVAPS-AE versus ST mode: A randomized controlled trial in patients with obesity hypoventilation syndrome},

author = {Maxime Patout and Frédéric Gagnadoux and Claudio Rabec and Wojciech Trzepizur and Marjolaine Georges and Christophe Perrin and Renaud Tamisier and Jean-Louis Pépin and Claudia Llontop and Valerie Attali and Frederic Goutorbe and Sandrine Pontier-Marchandise and Pierre Cervantes and Vanessa Bironneau and Adriana Portmann and Jacqueline Delrieu and Antoine Cuvelier and Jean-François Muir},

doi = {10.1111/resp.13784},

issn = {1440-1843},

year  = {2020},

date = {2020-10-01},

urldate = {2020-10-01},

journal = {Respirology},

volume = {25},

number = {10},

pages = {1073--1081},

abstract = {BACKGROUND AND OBJECTIVE: Average volume-assured pressure support-automated expiratory positive airway pressure (AVAPS-AE) combines an automated positive expiratory pressure to maintain upper airway patency to an automated pressure support with a targeted tidal volume. The aim of this study was to compare the effects of 2-month AVAPS-AE ventilation versus pressure support (ST) ventilation on objective sleep quality in stable patients with OHS. Secondary outcomes included arterial blood gases, health-related quality of life, daytime sleepiness, subjective sleep quality and compliance to NIV.



METHODS: This is a prospective multicentric randomized controlled trial. Consecutive OHS patients included had daytime P CO  > 6 kPa, BMI ≥ 30 kg/m , clinical stability for more than 2 weeks and were naive from home NIV. PSG were analysed centrally by two independent experts. Primary endpoint was sleep quality improvement at 2 months.



RESULTS: Among 69 trial patients, 60 patients had successful NIV setup. Baseline and follow-up PSG were available for 26 patients randomized in the ST group and 30 in the AVAPS-AE group. At baseline, P CO was 6.94 ± 0.71 kPa in the ST group and 6.61 ± 0.71 in the AVAPS-AE group (P = 0.032). No significant between-group difference was observed for objective sleep quality indices. Improvement in P CO was similar between groups with a mean reduction of -0.87 kPa (95% CI: -1.12 to -0.46) in the ST group versus -0.87 kPa (95% CI: -1.14 to -0.50) in the AVAPS-AE group (P = 0.984). Mean NIV use was 6.2 h per night in both groups (P = 0.93). NIV setup duration was shorter in the AVAPS-AE group (P = 0.012).



CONCLUSION: AVAPS-AE and ST ventilation for 2 months had similar impact on sleep quality and gas exchange.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32116800,

title = {Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data},

author = {Alain Boussuges and Sarah Rives and Marion Marlinge and Guillaume Chaumet and Nicolas Vallée and Régis Guieu and Olivier Gavarry},

doi = {10.3389/fphys.2020.00097},

issn = {1664-042X},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Front Physiol},

volume = {11},

pages = {97},

abstract = {INTRODUCTION: Adenosine is an ATP derivative that is strongly implicated in the cardiovascular adaptive response to exercise. In this study, we hypothesized that during exercise the hyperemia, commonly observed during exercise in air, was counteracted by the downregulation of the adenosinergic pathway during hyperoxic exposure.



METHODS: Ten healthy volunteers performed two randomized sessions including gas exposure (Medical air or Oxygen) at rest and during exercise performed at 40% of maximal intensity, according to the individual fitness of the volunteers. Investigations included the measurement of adenosine plasma level (APL) and the recording of hemodynamic data [i.e., cardiac output (CO) and systemic vascular resistances (SVR) using pulsed Doppler and echocardiography].



RESULTS: Hyperoxia significantly decreased APL (from 0.58 ± 0.06 to 0.21 ± 0.05 μmol L,  < 0.001) heart rate and CO and increased SVR in healthy volunteers at rest. During exercise, an increase in APL was recorded in the two sessions when compared with measurements at rest (+0.4 ± 0.4 vs. +0.3 ± 0.2 μmol L for medical air and oxygen exposures, respectively). APL was lower during the exercise performed under hyperoxia when compared with medical air exposure (0.5 ± 0.06 vs. 1.03 ± 0.2 μmol L, respectively  < 0.001). This result could contribute to the hemodynamic differences between the two conditions, such as the increase in SVR and the decrease in both heart rate and CO when exercises were performed during oxygen exposure as compared to medical air.



CONCLUSION: Hyperoxia decreased APLs in healthy volunteers at rest but did not eliminate the increase in APL and the decrease in SVR during low intensity exercise.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31156454,

title = {Mental Workload Alters Heart Rate Variability, Lowering Non-linear Dynamics},

author = {Stéphane Delliaux and Alexis Delaforge and Jean-Claude Deharo and Guillaume Chaumet},

doi = {10.3389/fphys.2019.00565},

issn = {1664-042X},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Front Physiol},

volume = {10},

pages = {565},

abstract = {Mental workload is known to alter cardiovascular function leading to increased cardiovascular risk. Nevertheless, there is no clear autonomic nervous system unbalance to be quantified during mental stress. We aimed to characterize the mental workload impact on the cardiovascular function with a focus on heart rate variability (HRV) non-linear indexes. A 1-h computerized switching task (letter recognition) was performed by 24 subjects while monitoring their performance (accuracy, response time), electrocardiogram and blood pressure waveform (finger volume clamp method). The HRV was evaluated from the beat-to-beat RR intervals (RRI) in time-, frequency-, and informational- domains, before (Control) and during the task. The task induced a significant mental workload (visual analog scale of fatigue from 27 ± 26 to 50 ± 31 mm,  < 0.001, and NASA-TLX score of 56 ± 17). The heart rate, blood pressure and baroreflex function were unchanged, whereas most of the HRV parameters markedly decreased. The maximum decrease occurred during the first 15 min of the task (P1), before starting to return to the baseline values reached at the end of the task (P4). The RRI dimension correlation (D2) decrease was the most significant (P1 vs. Control: 1.42 ± 0.85 vs. 2.21 ± 0.8,  < 0.001) and only D2 lasted until the task ended (P4 vs. Control: 1.96 ± 0.9 vs. 2.21 ± 0.9,  < 0.05). D2 was identified as the most robust cardiovascular variable impacted by the mental workload as determined by posterior predictive simulations ( = 0.9). The Spearman correlation matrix highlighted that D2 could be a marker of the generated frustration ( = -0.61,  < 0.01) induced by a mental task, as well as the myocardial oxygen consumption changes assessed by the double product ( = -0.53,  < 0.05). In conclusion, we showed that mental workload sharply lowered the non-linear RRI dynamics, particularly the RRI correlation dimension.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31281261b,

title = {High Bubble Grade After Diving: The Role of the Blood Pressure Regimen},

author = {Alain Boussuges and Guillaume Chaumet and Nicolas Vallée and Jean Jacques Risso and Jean Michel Pontier},

doi = {10.3389/fphys.2019.00749},

issn = {1664-042X},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Front Physiol},

volume = {10},

pages = {749},

abstract = { Previous studies have suggested that the circulatory system was involved in the production of circulatory bubbles after diving. This study was designed to research the cardio-vascular function characteristics related to the production of high bubble grades after diving.  Thirty trained divers were investigated both at baseline and after a 30-msw SCUBA dive. At baseline, the investigations included blood pressure measurement, echocardiography, and assessment of aerobic fitness using VO peak measurement. Blood samples were taken at rest, to measure the plasma concentration of NOx and endothelin-1. After diving, circulating bubbles were detected in the pulmonary artery by pulsed Doppler at 20-min intervals during the 90 min after surfacing. The global bubble quantity production was estimated by the KISS index.  Divers with a high bubble grade (KISS > 7.5) had systolic blood pressure, pulse pressure, weight, and height significantly higher than divers with a low bubble grade. By contrast, total arterial compliance, plasma NOx level, and percentage of predicted value of peak oxygen uptake were significantly lower in divers with a high bubble grade. Cardiac dimensions, left ventricular function, and plasma endothelin-1 concentration were not significantly different between groups. The multivariate analysis identified blood pressure as the main contributor of the quantity of bubble production. The model including pulse pressure, plasma NOx level, and percentage of predicted value of peak oxygen uptake has an explanatory power of 49.22%.  The viscoelastic properties of the arterial tree appeared to be an important contributor to the circulating bubble production after a dive.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid29721761,

title = {A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players},

author = {Olivier Gavarry and Gregory Lentin and Patrick Pezery and Anne Delextrat and Guillaume Chaumet and Alain Boussuges and Julien Piscione},

doi = {10.1186/s40798-018-0130-7},

issn = {2199-1170},

year  = {2018},

date = {2018-05-01},

urldate = {2018-05-01},

journal = {Sports Med Open},

volume = {4},

number = {1},

pages = {17},

abstract = {BACKGROUND: In some sports such as rugby, a large body size is an advantage, and the desire to gain weight can bring young players to become overweight or obese. The aim of this study was to evaluate the prevalence of overweight and obesity and the contribution of body fat mass index (BFMI) and fat-free mass index (FFMI) to body mass index (BMI) changes among young male rugby players (15-a-side rugby).



METHODS: The criteria of the International Obesity Task Force were used to define overweight and obesity from BMI. The method of skinfold thickness was used to assess percentage of body fat (%BF), BFMI, and FFMI. Excess body fat was defined by using BFMI and %BF above the 75th percentile. Data were grouped according to the age categories of the French Rugby Federation (U11, under 11 years; U13, under 13 years; U15, under 15 years) and to BMI status (NW normal-weight versus OW/OB overweight/obese).



RESULTS: Overall, 32.8% of the young players were overweight, and 13.8% were obese. However, 53% of young players classified as obese and overweight by BMI had an excess body fat by using BFMI above the 75th percentile. FFMI increased significantly between U11 and U13 in both groups, without significant change in BMI and BFMI. Both groups had similar significant gains in BMI and FFMI between U13 and U15, while BFMI only increased significantly in OW/OB (+ 18.5%). The strong correlations between BMI and %BF were systematically lower than those between BMI and BFMI. FFMI was strongly or moderately associated with BFMI.



CONCLUSIONS: Chart analysis of BFMI and FFMI could be used to distinguish changes in body composition across age categories in young male rugby players classified as normal-weight, overweight, and obese by BMI.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28975560,

title = {Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor},

author = {A Boussuges and K Ayme and G Chaumet and E Albier and M Borgnetta and O Gavarry},

doi = {10.1186/s40798-017-0104-1},

issn = {2199-1170},

year  = {2017},

date = {2017-10-01},

urldate = {2017-10-01},

journal = {Sports Med Open},

volume = {3},

number = {1},

pages = {35},

abstract = {BACKGROUND: The risk factors of pulmonary edema induced by diving in healthy subjects are not well known. The aim of the present study was to assess the parameters contributing to the increase in extravascular lung water after diving.



METHODS: This study was carried out in a professional diving institute. All divers participating in the teaching program from June 2012 to June 2014 were included in the study. Extravascular lung water was assessed using the detection of ultrasound lung comets (ULC) by chest ultrasonography. Clinical parameters and dive profiles were recorded using a questionnaire and a dive computer.



RESULTS: One-hundred six divers were investigated after 263 dives. They used an open-circuit umbilical supplying compressed gas diving apparatus in 202 cases and a self-contained underwater breathing apparatus in 61 cases. A generalized linear mixed model analysis was performed which demonstrated that the dive induced a significant increase in ULC score (incidence rate ratio: 3.16). It also identified that the predictive variable of increased extravascular lung water after the dive was the exercise intensity at depth (z = 3.99, p < 0.0001). The other parameters studied such as the water temperature, dive profile, hyperoxic exposure, or anthropometric data were not associated with the increase in extravascular lung water after the dive.



CONCLUSIONS: In this study, the exercise intensity was the main contributor to the increase in extravascular lung water in healthy divers. To improve the prevention of immersion pulmonary edema, the exercise intensity experienced during the dive should thus be adapted to the aerobic fitness level of the divers.},

keywords = {medical data},

pubstate = {published},

tppubtype = {article}

}