Omics data analysis

AltraBio's team implements and develops state-of-the-art and innovative methods for all kinds of omics studies (genomics, transcriptomics, proteomics,...).

AltraBio's Added Value

  • Time-proven and cutting-edge data analysis methodologies: building on the BioConductor software packages.
  • Extensive quality controls: applying its expertise to a wide variety of large-scale biological datasets, AltraBio performs extensive quality controls to identify potential outliers and check for consistency with the experimental design, thus ensuring the relevance and quality of downstream analyses.
  • Preprocessing and statistical analysis: AltraBio then provides the complete range of preprocessing and statistical analysis services relevant to all current omics technologies (e.g., identification of differentially expressed genes, SNP associations).

  • Functional analysis / Biological pathway identification: in the classical approach, omics analysis typically yields a list of differentially expressed molecules. AltraBio has expanded its statistical models to include analysis based on biological concepts, in which groups of molecules (rather than individual ones) that are informative for the experiment are identified. Besides including the pre-defined categories and annotations from resources such as Gene Ontology (GO), AltraBio has been building a collection of novel sets based on publicly available gene expression data and associated literature.

  • Biological interpretation: AltraBio's involvement in a project does not end with the generation of a list. Using the integrative, biological pathway-oriented approach, AltraBio analysts interpret the lists in the context of the biological problem the experiment addresses.
  • Access to WikiBioPath: this tool allows our partners to integrate and understand their experimental data (e.g., microarrays, RNAseq). Using WikiBioPath, one can search for targeted information on genes, proteins and their functional evidence extracted from unstructured textual knowledge repositories such as MEDLINE. WikiBioPath is further enriched by interactive data visualization tools which allow biologists to explore their experimental data and analyses results (Brochure).

  • Comprehensive report: The final result of AltraBio's work is a comprehensive report summarizing the experimental observations, discussing the biological mechanisms underlying the observed effects and, where appropriate, suggesting follow-up experiments to further elaborate on the results.

 

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